Recombination and repeat-induced point mutation landscapes reveal trade-offs between the sexual and asexual cycles of <i>Magnaporthe oryzae</i>

Xifang Zong; Yaxin Lou; Mengshuang Xia; Kunyang Zhao; Jingxuan Chen; Ju Huang; Sihai Yang; Long Wang

doi:10.1016/j.jgg.2024.03.003

Volume 51 Issue 7

Jul. 2024

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Article Navigation > Journal of Genetics and Genomics > 2024 > 51(7): 723-734

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Recombination and repeat-induced point mutation landscapes reveal trade-offs between the sexual and asexual cycles of Magnaporthe oryzae

doi: 10.1016/j.jgg.2024.03.003

a. State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, Jiangsu 210000, China;
b. State Key Laboratory for Crop Genetics and Germplasm Enhancement, Bioinformatics Center, Academy for Advanced Interdisciplinary Studies, Nanjing Agricultural University, Nanjing, Jiangsu 210000, China;
c. Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing, Jiangsu 210000, China

Funds:

This work was funded by the National Natural Science Foundation of China (32270664 and 32170327), the National Key Research and Development Program of China (2023YFD2200102 and 2023YFD2200104), and Jiangsu Collaborative Innovation Center for Modern Crop Production.

Received Date: 2024-01-30
Accepted Date: 2024-03-06
Rev Recd Date: 2024-03-01

Available Online: 2025-06-06

Publish Date: 2024-03-13

Abstract

Abstract

The fungal disease caused by Magnaporthe oryzae is one of the most devastating diseases that endanger many crops worldwide. Evidence shows that sexual reproduction can be advantageous for fungal diseases as hybridization facilitates host-jumping. However, the pervasive clonal lineages of M. oryzae observed in natural fields contradict this expectation. A better understanding of the roles of recombination and the fungi-specific repeat-induced point mutation (RIP) in shaping its evolutionary trajectory is essential to bridge this knowledge gap. Here we systematically investigate the RIP and recombination landscapes in M. oryzae using a whole genome sequencing data from 252 population samples and 92 cross progenies. Our data reveal that the RIP can robustly capture the population history of M. oryzae, and we provide accurate estimations of the recombination and RIP rates across different M. oryzae clades. Significantly, our results highlight a parent-of-origin bias in both recombination and RIP rates, tightly associating with their sexual potential and variations of effector proteins. This bias suggests a critical trade-off between generating novel allelic combinations in the sexual cycle to facilitate host-jumping and stimulating transposon-associated diversification of effectors in the asexual cycle to facilitate host coevolution. These findings provide unique insights into understanding the evolution of blast fungus.
- Magnaporthe oryzae,
- Crossover,
- Repeat-induced point mutation (RIP),
- Effectors,
- Sexual reproduction

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References(66)

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