Metagenomics analysis identifies oral <i>Streptococcus</i> as potential biomarkers for nasopharyngeal carcinoma

Yanmin Liu; Chengtao Wang; Lixiang Xie; Shuling Du; Li Ding; Ying Cui; Runzhi Chen; Jingxiang Zhang; Wan Wang; Xi Liu; Yan Wang; Shiyan Chen; Tian Tan; Qiaochu Zhao; Limei Yin; Chunwei Li; Yong Chen; Tao Ding

doi:10.1016/j.jgg.2023.11.003

Volume 51 Issue 3

Mar. 2024

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Article Navigation > Journal of Genetics and Genomics > 2024 > 51(3): 363-366

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Metagenomics analysis identifies oral Streptococcus as potential biomarkers for nasopharyngeal carcinoma

doi: 10.1016/j.jgg.2023.11.003

Yanmin Liu^1,2,
Chengtao Wang³,
Lixiang Xie^4,5,
Shuling Du^4,5,
Li Ding⁶,
Ying Cui^7,8,
Runzhi Chen^7,8,
Jingxiang Zhang^7,8,
Wan Wang^7,8,
Xi Liu⁹,
Yan Wang¹⁰,
Shiyan Chen¹¹,
Tian Tan^12,13,
Qiaochu Zhao^12,13,
Limei Yin^12,13,
Chunwei Li¹⁴,
Yong Chen¹⁵,
Tao Ding^16,17

1. Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;
2. Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong 510080, China;
3. Department of Radiation Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;
4. Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;
5. Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong 510080, China;
6. Department of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong 519000, China;
7. Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;
8. Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong 510080, China;
9. Department of Infectious Diseases, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong 519000, China;
10. Department of Radiation Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;
11. Department of Endocrinology & Metabolism, The Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong 519000, China;
12. Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;
13. Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong 510080, China;
14. Department of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;
15. Department of Radiation Oncology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;
16. Department of Immunology and Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China;
17. Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, Guangdong 510080, China

Funds:

D Program of China (2022YFA1204000 to T.D.), the Guangdong Key Area Research and Development Program (2019B020228001 to T.D.) and the National Natural Science Foundation of China (81971906 to T.D.).

We are grateful to the enrolled patients and volunteers who contributed generously to the work we performed. This study was approved by the Institutional Review Board of the First Affiliated Hospital of Sun Yat-sen University, No. (2019)212. The project was supported by the National Key R&

Received Date: 2023-07-11
Accepted Date: 2023-11-08
Rev Recd Date: 2023-11-08

Available Online: 2025-06-07

Publish Date: 2023-11-15

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References(20)

References

Bowen, W.H., Burne, R.A., Wu, H.,Koo, H., 2018. Oral biofilms: pathogens, matrix, and polymicrobial interactions in microenvironments. Trends Microbiol. 26, 229-242.

Butucel, E., Balta, I., Bundurus, I.A., Popescu, C.A., Iancu, T., Venig, A., Pet, I., Stef, D., McCleery, D., Stef, L., et al., 2023. Natural antimicrobials promote the anti-oxidative inhibition of COX-2 mediated inflammatory response in primary oral cells infected with Staphylococcus aureus, Streptococcus pyogenes and Enterococcus faecalis. Antioxidants (Basel) 12, 1017.

Chen, X., Li, Y.X., Cao, X., Qiang, M.Y., Liang, C.X., Ke, L.R., Cai, Z.C., Huang, Y.Y., Zhan, Z.J., Zhou, J.Y., et al., 2023. Widely targeted quantitative lipidomics and prognostic model reveal plasma lipid predictors for nasopharyngeal carcinoma. Lipids Health Dis. 22, 81.

Chen, Y.M., Tsai, P.H., Ye, Z.S., Huang, Y.W., Shieh, H.R., Wu, C.H., Lin, Y.J., Miller, J.H., Abranches, J.,Chiu, C.H., 2020. Functional Analysis of the collagen binding proteins of Streptococcus parasanguinis FW213. mSphere 5, e00863-20.

Cho, E., Park, S.N., Lim, Y.K., Shin, Y., Paek, J., Hwang, C.H., Chang, Y.H.,Kook, J.K., 2015. Fusobacterium hwasookii sp. nov., isolated from a human periodontitis lesion. Curr. Microbiol. 70, 169-175.

Debelius, J.W., Huang, T., Cai, Y., Ploner, A., Barrett, D., Zhou, X., Xiao, X., Li, Y., Liao, J., Zheng, Y., et al., 2020. Subspecies niche specialization in the oral microbiome is associated with nasopharyngeal carcinoma risk. mSystems 5, e00065-20.

Dzidic, M., Collado, M.C., Abrahamsson, T., Artacho, A., Stensson, M., Jenmalm, M.C.,Mira, A., 2018. Oral microbiome development during childhood: an ecological succession influenced by postnatal factors and associated with tooth decay. ISME J. 12, 2292-2306.

Elinav, E., Garrett, W.S., Trinchieri, G.,Wargo, J., 2019. The cancer microbiome. Nat. Rev. Cancer 19, 371-376.

Kulig, K., Kowalik, K., Surowiec, M., Karnas, E., Barczyk-Woznicka, O., Zuba-Surma, E., Pyza, E., Kozik, A., Rapala-Kozik, M.,Karkowska-Kuleta, J., 2023. Isolation and characteristics of extracellular vesicles produced by probiotics: Yeast Saccharomyces boulardii CNCM I-745 and Bacterium Streptococcus salivarius K12. Probiotics Antimicrob. Proteins. (in press).

Liao, Y., Zhang, J.B., Lu, L.X., Jia, Y.J., Zheng, M.Q., Debelius, J.W., He, Y.Q., Wang, T.M., Deng, C.M., Tong, X.T., et al., 2023. Oral Microbiota alteration and roles in Epstein-Barr virus reactivation in nasopharyngeal carcinoma. Microbiol Spectr. 11, e0344822.

Manzoor, S.S., Doedens, A.,Burns, M.B., 2020. The promise and challenge of cancer microbiome research. Genome Biol. 21, 131.

Metcalfe, S., Panasiewicz, M.,Kay, J.G., 2023. Inflammatory macrophages exploited by oral streptococcus increase IL-1B release via NLRP6 inflammasome. J. Leukoc Biol. 114, 347-357.

Sasaki, M., Yamaura, C., Ohara-Nemoto, Y., Tajika, S., Kodama, Y., Ohya, T., Harada, R.,Kimura, S., 2005. Streptococcus anginosus infection in oral cancer and its infection route. Oral Dis. 11, 151-156.

Toth, A.G., Judge, M.F., Nagy, S.A., Papp, M.,Solymosi, N., 2023. A survey on antimicrobial resistance genes of frequently used probiotic bacteria, 1901 to 2022. Euro. Surveill 28, 2200272.

Waldman, L.J., Butera, T., Boyd, J.D.,Grady, M.E., 2023. Sucrose-mediated formation and adhesion strength of Streptococcus mutans biofilms on titanium. Biofilm 6, 100143.

Wang, L., Wang, H., Zhang, H.,Wu, H., 2023. Formation of a biofilm matrix network shapes polymicrobial interactions. ISME J. 17, 467-477.

Xu, M., Yao, Y., Chen, H., Zhang, S., Cao, S.M., Zhang, Z., Luo, B., Liu, Z., Li, Z., Xiang, T., et al., 2019. Genome sequencing analysis identifies Epstein-Barr virus subtypes associated with high risk of nasopharyngeal carcinoma. Nat. Genet. 51, 1131-1136.

Xu, Y., Jia, Y., Chen, L., Gao, J.,Yang, D., 2021. Effect of Streptococcus anginosus on biological response of tongue squamous cell carcinoma cells. BMC Oral Health 21, 141.

Zhou, J., Deng, Y., Huang, Y., Wang, Z., Zhan, Z., Cao, X., Cai, Z., Deng, Y., Zhang, L., Huang, H., et al., 2023. An individualized prognostic model in patients with locoregionally advanced nasopharyngeal carcinoma based on serum metabolomic profiling. Life (Basel) 13, 1167.

Zhu, X.X., Yang, X.J., Chao, Y.L., Zheng, H.M., Sheng, H.F., Liu, H.Y., He, Y.,Zhou, H.W., 2017. The potential effect of oral microbiota in the prediction of mucositis during radiotherapy for nasopharyngeal carcinoma. EBioMedicine 18, 23-31.

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