Differential regulation of JAK1 expression by ETS1 associated with predisposition to primary biliary cholangitis

Peng Jiang; Chan Wang; Mingming Zhang; Ye Tian; Weifeng Zhao; Junyi Xin; Yexi Huang; Zhibin Zhao; Wenjuan Sun; Jie Long; Ruqi Tang; Fang Qiu; Xingjuan Shi; Yi Zhao; Li Zhu; Na Dai; Lei Liu; Xudong Wu; Jinshan Nie; Bo Jiang; Youlin Shao; Yueqiu Gao; Jianjiang Yu; Zhigang Hu; Zhidong Zang; Yuhua Gong; Yaping Dai; Lan Wang; Ningling Ding; Ping Xu; Sufang Chen; Lu Wang; Jing Xu; Luyao Zhang; Junyan Hong; Ruonan Qian; Hu Li; Xuan Jiang; Congwei Chen; Wenyan Tian; Jian Wu; Yuzhang Jiang; Chongxu Han; Kui Zhang; Hong Qiu; Li Li; Hong Fan; Liming Chen; Jianqiong Zhang; Zhongsheng Sun; Xiao Han; Zhenhua Dai; Erguang Li; M. Eric Gershwin; Zhexiong Lian; Xiong Ma; Michael F. Seldin; Weichang Chen; Meilin Wang; Xiangdong Liu

doi:10.1016/j.jgg.2023.06.004

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Differential regulation of JAK1 expression by ETS1 associated with predisposition to primary biliary cholangitis

doi: 10.1016/j.jgg.2023.06.004

1. Key Laboratory of Developmental Genes and Human Diseases, School of Life Science and Technology, Southeast University, Nanjing, Jiangsu 210096, China;
2. Institute of Translational Medicine, Yangzhou University Medical College, Yangzhou, Jiangsu 225009, China;
3. Department of Radiology & Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, China;
4. The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China;
5. Department of Genetic Toxicology, The Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, Nanjing Medical University School of Public Health, Nanjing, Jiangsu 210029, China;
6. Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, China;
7. Department of Gastroenterology and Hepatology, Shanghai Institute of Digestive Diseases, Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital, Shanghai 200001, China;
8. Department of Laboratory Medicine, The Fourth Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210031, China;
9. Department of Gastrointestinal Endoscopy, Eastern Hepatobiliary Surgery Hospital, Shanghai 201800, China;
10. The Fifth People's Hospital, Soochow University, Suzhou, Jiangsu 215007, China;
11. Department of Gastroenterology, Jiangsu University Affiliated Kunshan Hospital, Kunshan, Jiangsu 215300, China;
12. Department of Gastroenterology, Yixing People's Hospital, Yixin, Jiangsu 214200, China;
13. Department of Gastroenterology, Yancheng First People's Hospital, Yancheng, Jiangsu 224005, China;
14. Department of Gastroenterology, Taicang First People's Hospital, Soochow University, Taicang, Jiangsu 215400, China;
15. Department of Hepatology, Jingjiang Second People's Hospital, Jingjiang, Jiangsu 214500, China;
16. Department of Hepatology, The Third People's Hospital of Changzhou, Changzhou, Jiangsu 213001, China;
17. Department of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;
18. Department of Laboratory Medicine, Jiangyin People's Hospital, Southeast University, Jiangyin, Jiangsu 214400, China;
19. Department of Laboratory Medicine, Wuxi Children's Hospital, Wuxi, Jiangsu 214023, China;
20. Department of Hepatology, The Second Hospital of Nanjing, Southeast University, Nanjing, Jiangsu 210003, China;
21. Department of Laboratory Medicine, The Third People's Hospital of Zhenjiang, Zhenjiang, Jiangsu 212021, China;
22. Department of Laboratory Medicine, The Fifth People's Hospital of Wuxi, Wuxi, Jiangsu 214000, China;
23. Department of Laboratory Medicine, The 81th Hospital of PLA, Nanjing, Jiangsu 210002, China;
24. Department of Clinical Laboratory, Southeast University ZhongDa Hospital, Nanjing, Jiangsu 210009, China;
25. Department of Laboratory Medicine, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, China;
26. Department of Laboratory Medicine, Subei People's Hospital, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu 225001, China;
27. Department of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China;
28. Southeast University Medical College, Nanjing, Jiangsu 210009, China;
29. Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Institute of cancer, Department of biochemistry, Nanjing Normal University College of Life Sciences, Nanjing, Jiangsu 210023, China;
30. Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China;
31. Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu 211166, China;
32. Section of Immunology & Joint Immunology Program, the Second Clinical Medical College of Guangzhou University of Chinese Medicine, and Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, Guangdong 510006, China;
33. Jiangsu Laboratory of Molecular Medicine, Nanjing University Medical School, Nanjing, Jiangsu 210093, China;
34. Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, Davis, CA, 95616, USA;
35. Department of Biochemistry and Molecular Medicine, University of California at Davis School of Medicine, Davis, CA, 95616, USA

Funds:

This study was partially supported by grants from the National Natural Science Foundation of China (Nos. 81870397, 82000534, and 82073156), Shenzhen Kangzhe Pharmaceutical Co. Ltd (URC-126/PBC), The Fifth Suzhou Health Talent Project (GSWS201903) and The Suzhou Radiotherapy Clinical Medical Center Project (Szlcyxzx202103).

Received Date: 2023-01-20
Accepted Date: 2023-06-07
Rev Recd Date: 2023-06-05

Available Online: 2023-06-21

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References

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