a Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;
b Graduate College, Beijing University of Chinese Medicine, Beijing 100029, China;
c Department of Scientific Research, Changchun University of Chinese Medicine, Changchun, Jilin 130017, China;
d Molecular Biology Laboratory, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China;
e Institute of Metabolic Diseases, Guang'anmen Hospital of China, Academy of Chinese Medical Sciences, Beijing 100053, China
Funds:
This work was supported by the National Natural Science Foundation of China (81973837), Scientific and technological innovation project of China Academy of Chinese Medical Sciences (CI2021A016), and National Key projects for international cooperation on science, technology and innovation (2021YFE0201100).
Interactions between diet and the intestinal microbiome play an important role in human health and disease development. It is well known that such interactions, whether direct or indirect, trigger a series of metabolic reactions in the body. Evidence suggests that intestinal stem cells (ISCs), which are phenotypic precursors of various intestinal epithelial cells, play a significant role in the regulation of intestinal barrier function and homeostasis. The advent and evolution of intestinal organoid culture techniques have presented a key opportunity to study the association between the intestinal microenvironment and ISCs. As a result, the effects exerted by dietary factors, intestinal microbiomes, and their metabolites on the metabolic regulation of ISCs and the potential mechanisms underlying such effects are being gradually revealed. This review summarises the effects of different dietary patterns on the behaviour and functioning of ISCs and focuses on the cross-talk between intestinal microbiota, related metabolites, and ISCs, with the aim of fully understanding the relationship between these three factors and providing further insights into the complex mechanisms associated with ISCs in the human body. Gaining an understanding of these mechanisms may lead to the development of novel dietary interventions or drugs conducive to intestinal health.