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Volume 49 Issue 12
Dec.  2022
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Article Contents

Molecular spectrum of thalassemia in tropical Hainan Island of southern China: high allele frequency with low health burden

doi: 10.1016/j.jgg.2022.03.010
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This work was supported by grants from the Natural Science Foundation of China (81972008) and Guangdong Basic and Applied Basic Research Foundation (2021A1515012585).

  • Received Date: 2022-02-10
  • Accepted Date: 2022-03-30
  • Rev Recd Date: 2022-03-28
  • Publish Date: 2022-04-06
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  • Amaratunga, C., Fairhurst, R.M., 2014. α+-Thalassemia antagonizes the malaria-protective effects of sickle-cell trait. EBioMedicine. 1, 8-9
    Chen, M., Zhang, M., Chen, L., Lin, N., Wang, Y., Xu, L., Huang, H., 2022. Genetic research and clinical analysis of β-globin gene cluster deletions in the Chinese population of Fujian province: a 14-year single-center experience. J. Clin. Lab. Anal.36, e24181
    Huang, J.W., Shang, X., Zhao, Y., Cai, R., Zhang, X.H., Wei, X.F., Xiong, F., Xu, X.M., 2013. A novel fusion gene and a common α0-thalassemia deletion cause hemoglobin H disease in a Chinese family. Blood Cells Mol. Dis.51, 31-34
    Kariuki, S.N., Williams, T.N., 2020. Human genetics and malaria resistance. Hum. Genet. 139, 801-811
    Kwiatkowski, D.P., 2005. How malaria has affected the human genome and what human genetics can teach us about malaria. Am. J. Hum. Genet.77, 171-192
    Lai, K., Huang, G., Su, L., He, Y., 2017. The prevalence of thalassemia in mainland China: evidence from epidemiological surveys. Sci. Rep. 7, 920
    Lopera-Mesa, T.M., Doumbia, S., Konate, D., Anderson, J.M., Doumbouya, M., Keita, A.S., Diakite, S.A., Traore, K., Krause, M.A., Diouf, A., et al., 2015. Effect of red blood cell variants on childhood malaria in Mali: a prospective cohort study. Lancet Haematol. 2, e140-149
    Musallam, K.M., Bou-Fakhredin, R., Cappellini, M.D., Taher, A.T., 2021. 2021 update on clinical trials in β-thalassemia. Am. J. Hematol. 96,1518-1531
    Shang, X., Peng, Z., Ye, Y., Asan, Zhang, X., Chen, Y., Zhu, B., Cai, W., Chen, S., Cai, R., et al., 2017. Rapid targeted next-generation sequencing platform for molecular screening and clinical genotyping in subjects with hemoglobinopathies. EBioMedicine. 23, 150-159
    Taher, A.T., Weatherall, D.J., Cappellini, M.D., 2018. Thalassaemia. Lancet. 391,155-167
    Tan, M., Bai, Y, Zhang, X., Sun, J., Huang, C., Tian, R., Yang, Y., Luo, X., Su, Q., Wu, L., et al., 2021. Early genetic screening uncovered a high prevalence of thalassemia among 18309 neonates in Guizhou, China. Clin. Genet. 99, 704-712
    Vlok, M., Buckley, H.R., Miszkiewicz, J.J., Walker, M.M., Domett, K., Willis, A., Trinh, H.H., Minh, T.T., Nguyen, M.H.T., Nguyen, L.C., et al., 2021. Forager and farmer evolutionary adaptations to malaria evidenced by 7000 years of thalassemia in Southeast Asia. Sci. Rep. 11, 5677
    Wu, M.Y., Li, J., Li, S.C., Li, Y., Li, D.Z., 2015. Frequencies of HKαα and anti-HKαα alleles in Chinese carriers of silent deletional α-thalassemia. Hemoglobin.39,407-411
    Wu, Y., Yao, Q., Zhong, M., Wu, J., Xie, L., Su, L., Yu, F., 2020. Genetic research and clinical analysis of deletional Chinese Gγ+(Aγδβ)0-thalassemia and Southeast Asian HPFH in South China. Ann. Hematol.;99:2747-2753
    Xiong, F., Sun, M., Zhang, X., Cai, R., Zhou, Y., Lou, J., Zeng, L., Sun, Q., Xiao, Q., Shang, X., et al., 2010. Molecular epidemiological survey of haemoglobinopathies in the Guangxi Zhuang Autonomous Region of southern China. Clin. Genet. 78, 139-148
    Xu, X.M., Zhou, Y.Q., Luo, G.X., Liao, C., Zhou, M., Chen, P.Y., Lu, J.P., Jia, S.Q., Xiao, G.F., Shen, X., et al., 2004. The prevalence and spectrum of alpha and beta thalassaemia in Guangdong Province: implications for the future health burden and population screening. J. Clin. Pathol. 57, 517-522
    Yao, H., Chen, X., Lin, L., Wu, C., Fu, X., Wang, H., Yao, Z., Chen, W., Huang, L., Tang, R., et al., 2014. The spectrum of α- and β-thalassemia mutations of the Li people in Hainan Province of China. Blood Cells Mol. Dis. 53,16-20
    Zhong, L., Gan, X., Xu, L., Liang, C., Xie, Y., Lin, W., Chen, P., Liu, M., 2018. The phenomena of balanced effect between α-globin gene and of β-globin gene. BMC Med. Genet.19, 145
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