The composition, function, and regulation of adipose stem and progenitor cells

Xiyan Liao; Haiyan Zhou; Tuo Deng

doi:10.1016/j.jgg.2022.02.014

Volume 49 Issue 4

Apr. 2022

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Article Navigation > Journal of Genetics and Genomics > 2022 > 49(4): 308-315

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The composition, function, and regulation of adipose stem and progenitor cells

doi: 10.1016/j.jgg.2022.02.014

Xiyan Liao^a,b,
Haiyan Zhou^c,d,
Tuo Deng^a,b,e

a National Clinical Research Center for Metabolic Diseases, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China;
b Key Laboratory of Diabetes Immunology, Ministry of Education, and Metabolic Syndrome Research Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China;
c Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China;
d National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan 410008, China;
e Clinical Immunology Center, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410000, China

Funds:

This work was supported by the National Key R&

D Program of China (2020YFA0803604), the National Natural Science Foundation of China (81770868, 91742103, 82130024 and 82170866), the Science and Technology Innovation Program of Hunan Province (2020RC4009) and the Project of Innovation-Driven Plan of Central South University (2020CX015).

Received Date: 2021-11-16
Accepted Date: 2022-02-20
Rev Recd Date: 2022-02-18
Publish Date: 2022-04-30

Abstract

Abstract

White adipose tissue (WAT) is a highly plastic organ that plays a central role in regulating whole-body energy metabolism. Adipose stem and progenitor cells (ASPCs) are essential components of the stromal vascular fraction (SVF) of adipose tissue. They give rise to mature adipocytes and play a critical role in maintaining adipose tissue function. However, the molecular heterogeneity and functional diversity of ASPCs are still poorly understood. Recently, single-cell RNA sequencing (scRNA-seq) analysis has identified distinct subtypes of ASPCs in murine and human adipose tissues, providing new insights into the cellular complexity of ASPCs among multiple fat depots. This review summarizes the current knowledge on ASPC populations, including their markers, functions, and regulatory mechanisms. Targeting one or several of these cell populations may ameliorate metabolic disorders by promoting adaptive hyperplastic adipose growth.
- Adipose tissue,
- ASPCs,
- scRNA-seq,
- Committed preadipocytes,
- Regulatory progenitors

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References(58)

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