Genome-wide analyses of nonsyndromic cleft lip with or without palate identify 20 new risk loci in the Chinese Han population

Bao Li; Liang Yong; Yafen Yu; Yanqin Yu; Qi Zhen; Huiyao Ge; Yiwen Mao; Weiwei Chen; Yanxia Yu; Yirui Wang; Zhuo Li; Wencheng Fan; Chang Zhang; Xia Hu; Ruixue Zhang; Lu Cao; Hao Liu; Zhuan Bian; Miao He; Liangdan Sun

doi:10.1016/j.jgg.2022.02.004

Volume 49 Issue 9

Sep. 2022

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Genome-wide analyses of nonsyndromic cleft lip with or without palate identify 20 new risk loci in the Chinese Han population

doi: 10.1016/j.jgg.2022.02.004

Bao Li^1,2,3,4,5,
Liang Yong^1,2,3,4,5,
Yafen Yu^1,2,3,4,5,
Yanqin Yu⁶,
Qi Zhen^7,8,9,10,11,
Huiyao Ge^7,8,9,10,11,
Yiwen Mao^7,8,9,10,11,
Weiwei Chen^7,8,9,10,11,
Yanxia Yu^7,8,9,10,11,
Yirui Wang^7,8,9,10,11,
Zhuo Li^7,8,9,10,11,
Wencheng Fan^7,8,9,10,11,
Chang Zhang^7,8,9,10,11,
Xia Hu^7,8,9,10,11,
Ruixue Zhang^7,8,9,10,11,
Lu Cao^7,8,9,10,11,
Hao Liu^7,8,9,10,11,
Zhuan Bian¹²,
Miao He¹²,
Liangdan Sun^{13,14,15,16,17}

1. Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China;
2. Institute of Dermatology, Anhui Medical University, Hefei, China;
3. Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui 230022, China;
4. Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui 230022, China;
5. Anhui Provincial Institute of Translational Medicine, Hefei, Anhui 230022, China;
6. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, China;
7. Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China;
8. Institute of Dermatology, Anhui Medical University, Hefei, Anhui 230022, China;
9. Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui 230022, China;
10. Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui 230022, China;
11. Anhui Provincial Institute of Translational Medicine, Hefei, Anhui 230022, China;
12. The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, China;
13. Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China;
14. Institute of Dermatology, Anhui Medical University, Hefei, Anhui 230022, China;
15. Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, Anhui 230022, China;
16. Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, Anhui 230022, China;
17. Anhui Provincial Institute of Translational Medicine, Hefei, Anhui 230022, China

Funds:

This work was funded by the National Natural Science Foundation of China (81970904 to MH, 81970923 to ZB), Anhui Institute of Translational Medicine (ZHYX2020A005 to LS), the University Synergy Innovation Program of Anhui Province (GXXT-2020-064 to LS), Clinical medicine discipline construction project of Anhui Medical University (2021lcxk008 to LS), and the National Key Research and Development Program (2016YFC1000505 to ZB).

Received Date: 2021-09-27
Accepted Date: 2022-02-13
Rev Recd Date: 2022-01-16
Publish Date: 2022-02-22

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