BAP60 plays an opposite role to the MRT-NURF complex in regulating lipid droplet size

Yan Yao; Mengyao Xu; Lianyong Qiao; Hu Nie; Falong Lu; Xun Huang

doi:10.1016/j.jgg.2022.02.003

Volume 49 Issue 4

Apr. 2022

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Article Navigation > Journal of Genetics and Genomics > 2022 > 49(4): 377-379

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BAP60 plays an opposite role to the MRT-NURF complex in regulating lipid droplet size

doi: 10.1016/j.jgg.2022.02.003

1. State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China;
2. University of Chinese Academy of Sciences, Beijing 100049, China

Funds:

D Program of China and the National Natural Science Foundation of China, respectively.

This research was supported by grants 2018YFA0506902 and 91954207 from the National Key R&

Received Date: 2021-12-11
Publish Date: 2022-04-30

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References(16)

References

Badenhorst, P., Xiao, H., Cherbas, L., Kwon, S.Y., Voas, M., Rebay, I., Cherbas, P., Wu, C., 2005. The Drosophila nucleosome remodeling factor NURF is required for ecdysteroid signaling and metamorphosis. Genes Dev. 19, 2540-2545

Farmer, B.C., Walsh, A.E., Kluemper, J.C., Johnson, L.A., 2020. Lipid droplets in neurodegenerative disorders. Front. Neurosci. 14, 742

Gong, J., Sun, Z., Li, P., 2009. CIDE proteins and metabolic disorders. Curr. Opin. Lipidol. 20, 121-126

Greenberg, A.S., Coleman, R.A., Kraemer, F.B., McManaman, J.L., Obin, M.S., Puri, V., Yan, Q.W., Miyoshi, H., Mashek, D.G., 2011. The role of lipid droplets in metabolic disease in rodents and humans. J. Clin. Invest. 121, 2102-2110

Krahmer, N., Farese, R.V., Jr, Walther, T.C., 2013. Balancing the fat: lipid droplets and human disease. EMBO Mol. Med. 5, 973-983

Kugler, S.J., Gehring, E.M., Wallkamm, V., Kruger, V., Nagel, A.C. 2011. The Putzig-NURF nucleosome remodeling complex is required for ecdysone receptor signaling and innate immunity in Drosophila melanogaster. Genetics 188, 127-139

Li, S., Liu, C., Li, N., Hao, T., Han, T., Hill, D.E., Vidal, M., Lin, J.D., 2008. Genome-wide coactivation analysis of PGC-1alpha identifies BAF60a as a regulator of hepatic lipid metabolism. Cell Metabol. 8, 105-117

Teixeira, V., Maciel, P., Costa, V., 2021. Leading the way in the nervous system: lipid droplets as new players in health and disease. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1866, 158820

Tzika, E., Dreker, T., Imhof, A., 2018. Epigenetics and metabolism in health and disease. Front. Genet. 9, 361

van Dijk, S.J., Tellam, R.L., Morrison, J.L., Muhlhausler, B.S., Molloy, P.L., 2015. Recent developments on the role of epigenetics in obesity and metabolic disease. Clin. Epigenet. 7, 66

Wang, R.R., Pan, R., Zhang, W., Fu, J., Lin, J.D., Meng, Z.X., 2018. The SWI/SNF chromatin-remodeling factors BAF60a, b, and c in nutrient signaling and metabolic control. Protein Cell 9, 207-215

Wang, Y., Wong, R.H., Tang, T., Hudak, C.S., Yang, D., Duncan, R.E., Sul, H.S., 2013. Phosphorylation and recruitment of BAF60c in chromatin remodeling for lipogenesis in response to insulin. Mol. Cell 49, 283-297

Yao, Y., Li, X., Wang, W., Liu, Z., Chen, J., Ding, M., Huang, X., 2018. MRT, functioning with NURF complex, regulates lipid droplet size. Cell Rep. 24, 2972-2984

Yu, J., Li P., 2017. The size matters: regulation of lipid storage by lipid droplet dynamics. Sci. China Life Sci. 60, 46-56

Zhang, P., Li, L., Bao, Z., Huang, F., 2016. Role of BAF60a/BAF60c in chromatin remodeling and hepatic lipid metabolism. Nutr. Metab. 13, 30

Zraly, C.B., Middleton, F.A., Dingwall, A.K., 2006. Hormone-response genes are direct in vivo regulatory targets of Brahma (SWI/SNF) complex function. J. Biol. Chem. 281, 35305-35315

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