The gut microbiome and microbial metabolites in acute myocardial infarction

Chenglin Liu; Zhonghan Sun; Shalaimaiti Shali; Zhendong Mei; Shufu Chang; Hanjun Mo; Lili Xu; Yanni Pu; Huihui Guan; Guo-Chong Chen; Qibin Qi; Zhexue Quan; Ji Qi; Kang Yao; Yuxiang Dai; Yan Zheng; Junbo Ge

doi:10.1016/j.jgg.2021.12.007

Volume 49 Issue 6

Jun. 2022

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Article Navigation > Journal of Genetics and Genomics > 2022 > 49(6): 569-578

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The gut microbiome and microbial metabolites in acute myocardial infarction

doi: 10.1016/j.jgg.2021.12.007

a. State Key Laboratory of Genetic Engineering, School of Life Sciences and Human Phenome Institute, Fudan University, Shanghai 200433, China;
b. Ministry of Education Key Laboratory of Contemporary Anthropology, Fudan University, Shanghai 200433, China;
c. Department of Cardiology, Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, 1609 Xietu Road, Shanghai 200032, China;
d. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA;
e. Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, Institute of Biodiversity Science, School of Life Sciences, Fudan University, Shanghai 200433, China

Funds:

D Program of China at the Ministry of Science and Technology of the People's Republic of China (Grant No. 2021YFA301003), the Clinical Research Plan of Shanghai Hospital Development Center at the Shanghai Hospital Development Center (Grant No. SHDC2020CR1007A), the Shanghai Municipal Science and Technology Major Project at the Science and Technology Commission of Shanghai Municipality (Grant No. 2017SHZDZX01), and the General Program at the National Natural Science Foundation of China (Grant No. 81973032). Y.Z. was supported by the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning.

This project was supported by the National Key R&

Received Date: 2021-08-31
Accepted Date: 2021-12-12
Rev Recd Date: 2021-12-11
Publish Date: 2022-06-30

Abstract

Abstract

Emerging evidence has highlighted the role of gut microbiome in human health. However, the integrative role of gut microbiome and microbial metabolites in acute myocardial infarction (AMI) remains unclear. The current study profiles the microbial community through 16S rRNA gene sequencing and shotgun metagenomic sequencing and measures fecal short-chain fatty acids and circulating choline pathway metabolites among 117 new-onset AMI cases and 78 controls. Significant microbial alternations are observed in AMI patients compared with controls (P=0.001). The abundances of nine species (e.g., Streptococcus salivarius and Klebsiella pneumoniae) are positively associated, and one species (Roseburia hominis) is inversely associated with AMI status and severity. A gut microbial score at disease onset is associated with the risk of major adverse cardiovascular events in 3.2 years (hazard ratio[95% CI]:2.01[1.04-4.24]) in AMI patients. The molar proportions of fecal acetate and butyrate are higher, and the circulating levels of choline and carnitine are lower in AMI patients than in controls. In addition, disease classifiers show that AMI cases and controls have a more distinct pattern in taxonomical composition than in pathways or metabolites. Our findings suggest that microbial composition and functional potentials are associated with AMI status and severity.
- Acute myocardial infarction,
- Atherosclerosis,
- Microbiome,
- Short-chain fatty acids

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References(52)

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