Effects of interaction between single nucleotide polymorphisms and psychosocial factors on the response to antidepressant treatment in patients with major depressive disorder

Di Luan; Dongfang You; Yaqian Wu; Fangfang Wu; Zhi Xu; Ling Li; Jiao Jiao; Aini Zhang; Haixia Feng; Yan Kong; Yang Zhao; Zhijun Zhang

doi:10.1016/j.jgg.2021.11.012

Volume 49 Issue 6

Jun. 2022

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Article Navigation > Journal of Genetics and Genomics > 2022 > 49(6): 587-589

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Effects of interaction between single nucleotide polymorphisms and psychosocial factors on the response to antidepressant treatment in patients with major depressive disorder

doi: 10.1016/j.jgg.2021.11.012

Di Luan¹,
Dongfang You^2,3,
Yaqian Wu⁴,
Fangfang Wu⁵,
Zhi Xu⁶,
Ling Li⁷,
Jiao Jiao⁷,
Aini Zhang⁷,
Haixia Feng⁸,
Yan Kong⁹,
Yang Zhao^10,11,12,13,
Zhijun Zhang^14,15

1. Department of Neurology, Affiliated Zhongda Hospital, Research Institution of Neuropsychiatry, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China;
2. Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China;
3. Department of Environmental Health, Harvard T.H. C1han School of Public Health, Harvard University, Boston 02115, USA;
4. Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China;
5. Department of Immunology and Medical Microbiology, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210046, China;
6. Department of Psychosomatics and Psychiatry, Affiliated Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China;
7. Department of Neurology, Affiliated Zhongda Hospital, Research Institution of Neuropsychiatry, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China;
8. Department of Nursing, Affiliated Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China;
9. Department of Biochemistry and Molecular Biology, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China;
10. Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China;
11. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Harvard University, Boston 02115, USA;
12. China International Cooperation Center for Environment and Human Health, Center for Global Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China;
13. The Center of Biomedical Big Data and the Laboratory of Biomedical Big Data, Nanjing Medical University, Nanjing, Jiangsu 211166, China;
14. Department of Neurology, Affiliated Zhongda Hospital, Research Institution of Neuropsychiatry, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China;
15. Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong 518055, China

Funds:

D Program of China (2016YFC1306700)

We would like to thank all patients with major depressive disorder and all scientific researchers who participated in this study for their dedication. This work was partly supported by the National Key R&

the Program of Excellent Talents in Medical Science of Jiangsu Province, China (JCRCA2016006)

the Science and Technology Program of Guangdong, China (2018B030334001)

the Key Projects of National Natural Science Foundation of China (81830040 and 82130042)

and the Social Science Foundation of Jiangsu Province, China (19GLB025).

Received Date: 2021-07-15
Accepted Date: 2021-11-27
Rev Recd Date: 2021-11-21
Publish Date: 2022-06-30

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