Sequence motifs and prediction model of GBE editing outcomes based on target library analysis and machine learning

Bo Li; Ya-Qiu Li; Dongdong Zhao; Jie Yang; Yan-He Ma; Chang-Hao Bi; Xue-Li Zhang

doi:10.1016/j.jgg.2021.11.007

Volume 49 Issue 3

Mar. 2022

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Article Navigation > Journal of Genetics and Genomics > 2022 > 49(3): 254-257

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Sequence motifs and prediction model of GBE editing outcomes based on target library analysis and machine learning

doi: 10.1016/j.jgg.2021.11.007

Bo Li^1,2,3,4,
Ya-Qiu Li^5,6,7,
Dongdong Zhao^5,6,7,
Jie Yang^8,9,10,11,
Yan-He Ma^12,13,14,
Chang-Hao Bi^12,13,14,
Xue-Li Zhang^12,13,14

1. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China;
2. University of Chinese Academy of Sciences, Beijing 100049, China;
3. Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China;
4. National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China;
5. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China;
6. Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China;
7. National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China;
8. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China;
9. Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China;
10. National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China;
11. College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300308, China;
12. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China;
13. Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China;
14. National Technology Innovation Center of Synthetic Biology, Tianjin 300308, China

Funds:

This work was financially supported by the National Key Research and Development Program of China (2018YFA0903700), the National Natural Science Foundation of China (31861143019, 31770105, 32001041), a Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project (TSBICIP-KJGG-001) and Tianjin Natural Science Foundation (20JCYBJC00310).

Received Date: 2021-07-02
Accepted Date: 2021-11-14
Rev Recd Date: 2021-11-08
Publish Date: 2021-12-02

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References(19)

References

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