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Volume 49 Issue 1
Jan.  2022
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Article Navigation >  Journal of Genetics and Genomics  > 2022  >  49(1): 1-12

Genetics of anorexia nervosa: An overview of genome-wide association studies and emerging biological links

doi: 10.1016/j.jgg.2021.09.005
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    a Department of Neuroscience, Functional Pharmacology, Uppsala University, Uppsala, Sweden;

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    b Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy;

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    c School of Psychology, Faculty of Health, Liverpool John Moores University, UK;

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    d Department of Psychology, School of Human and Community Development, University of the Witwatersrand, Johannesburg, South Africa;

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    e Institute for Translational Medicine and Biotechnology, Sechenov First Moscow State Medical University, Moscow, Russia

Funds:

Gull Rukh was supported by the grant from Svenska Sällskapet för Medicinsk Forskning (SSMF). Helgi Birgir Schiöth was supported by the grant from Swedish Research Council (VR 2014-02812). The funding bodies had no role in the design, preparation or approval of the manuscript.

  • Received Date: 2021-03-01
  • Accepted Date: 2021-09-28
  • Rev Recd Date: 2021-09-28
  • Publish Date: 2021-10-08
    Abstract
  • Anorexia nervosa (AN) is a complex disorder with a strong genetic component. Comorbidities are frequent and there is substantial overlap with other disorders. The lack of understanding of the molecular and neuroanatomical causes has made it difficult to develop effective treatments and it is often difficult to treat in clinical practice. Recent advances in genetics have changed our understanding of polygenic diseases, increasing the possibility of understanding better how molecular pathways are intertwined. This review synthetizes the current state of genetic research providing an overview of genome-wide association studies (GWAS) findings in AN as well as overlap with other disorders, traits, pathways, and imaging results. This paper also discusses the different putative global pathways that are contributing to the disease including the evidence for metabolic and psychiatric origin of the disease.
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