Long-range gene regulation network of the <i>MGMT</i> enhancer modulates glioma cell sensitivity to temozolomide

Bohan Chen; Anshun He; Jinfang Bi; Shupeng Sun; Yiping Ma; Wenbin Wang; Dianhao Guo; Jun Chen; Yuyang Qian; Tengfei Shi; Guohui Nie; Zhongfang Zhao; Jiandang Shi; Hongzhen Yang; Lei Zhang; Wange Lu

doi:10.1016/j.jgg.2021.06.015

Volume 48 Issue 10

Oct. 2021

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Article Navigation > Journal of Genetics and Genomics > 2021 > 48(10): 946-949

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Long-range gene regulation network of the MGMT enhancer modulates glioma cell sensitivity to temozolomide

doi: 10.1016/j.jgg.2021.06.015

a. State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China;
b. Department of Neurosurgery, Tianjin Huanhu Hospital, School of Medicine, Nankai University, 6 Jizhao Road, Tianjin 300350, China;
c. Department of Otolaryngology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen 518035, China

Funds:

This work was supported by the National Natural Science Foundation of China (31701129, 31530027, and 81772687), the Natural Science Foundation of Tianjin City of China (20JCQNJC01880, 18JCQNJC10100, and 18JCQNJC09800), National Key R&D Program of China (2017YFA0102600) and the Fundamental Research Funds for the Central Universities, Nankai University (63201087). We thank Dr. Lingyi Chen at the College of Life Sciences of Nankai University for providing Cas9 plasmids.

Received Date: 2021-02-04
Publish Date: 2021-07-14

Abstract

These authors contributed equally to this work.

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References(20)

References

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