Ether phospholipids govern ferroptosis

Lee Hyemin; Zhuang Li; Gan Boyi

doi:10.1016/j.jgg.2021.05.003

Volume 48 Issue 7

Jul. 2021

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Article Navigation > Journal of Genetics and Genomics > 2021 > 48(7): 517-519

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Ether phospholipids govern ferroptosis

doi: 10.1016/j.jgg.2021.05.003

a Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA;
b The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA

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We apologize to the colleagues whose relevant work cannot be cited here because of space limitations. Research in the authors' laboratory has been supported by The University of Texas MD Anderson Cancer Center, National Institutes of Health grants (R01CA181196, R01CA244144, and R01CA247992 to B. Gan) and by Cancer Center Support (Core) Grant P30 (CA016672 from the National Cancer Institute to The University of Texas MD Anderson Cancer Center).

Received Date: 2021-03-26
Accepted Date: 2021-05-08
Rev Recd Date: 2021-04-13
Publish Date: 2021-07-20

Abstract

Abstract

Ferroptosis is a cell death modality triggered by excessive lipid peroxidation. Two recent studies (Zou et al., 2020; Cui et al., 2021) not only reveal critical roles of ether-linked phospholipids as an additional source for providing polyunsaturated fatty acid-containing phospholipids in driving ferroptosis but also suggest a context-dependent role of TMEM189-mediated vinyl-ether phospholipid (plasmalogen) synthesis in ferroptosis.
- Ferroptosis,
- Lipid peroxidation,
- Ether phospholipids,
- Plasmalogen,
- TMEM189

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References(11)

References

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