Juvenile hormone receptor Met regulates sleep and neuronal morphology via glial-neuronal crosstalk

Binbin Wu; Lei He; Yutong Xiao; Juan Du; Xiaoxiao Wang; Zhangwu Zhao

doi:10.1016/j.jgg.2021.04.010

Volume 48 Issue 8

Aug. 2021

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Article Navigation > Journal of Genetics and Genomics > 2021 > 48(8): 706-715

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Juvenile hormone receptor Met regulates sleep and neuronal morphology via glial-neuronal crosstalk

doi: 10.1016/j.jgg.2021.04.010

a Department of Entomology and MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing 100193, China;
b College of Life Sciences, Hebei University, Baoding 071002, China

Funds:

We thank Jeffrey Price (University of Missouri at Kansas City) for revising this manuscript. This work was supported by the National Natural Science Foundation of China Grants 31970458 and 31730076 (to Z.W. Zhao).

Received Date: 2021-01-07
Accepted Date: 2021-04-14
Rev Recd Date: 2021-04-05
Publish Date: 2021-08-20

Abstract

Abstract

Juvenile hormone (JH) is one of the most important hormones in insects since it is essential for insect development. The mechanism by which JH affects the central nervous system still remains a mystery. In this study, we demonstrate that one of the JH receptors, Methoprene-tolerant (Met), is important for the control of neurite development and sleep behavior in Drosophila. With the identification of Met-expressing glial cells, the mechanism that Met negatively controls the mushroom body (MB) β lobes fusion and positively maintains pigment-dispersing factor sLNvs projection pruning has been established. Furthermore, despite the developmental effects, Met can also maintain nighttime sleep in a development-independent manner through the α/β lobe of MB. Combining analyses of neuronal morphology and entomological behavior, this study advances our understanding of how the JH receptor regulates the nervous system.
- Met,
- Sleep,
- Glial cells,
- Drosophila,
- Mushroom body,
- PDF projection

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References(43)

References

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