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Volume 48 Issue 5
May  2021
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Article Navigation >  Journal of Genetics and Genomics  > 2021  >  48(5): 369-383

Arabidopsis RPD3-like histone deacetylases form multiple complexes involved in stress response

doi: 10.1016/j.jgg.2021.04.004
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    a College of Life Sciences, Beijing Normal University, Beijing 100875, China;

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    b National Institute of Biological Sciences, Beijing 102206, China;

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    c Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 10084, China

Funds:

This work was supported by the National Natural Science Foundation of China (32025003) and by the National Key Research and Development Program of China (2016YFA0500801) from the Chinese Ministry of Science and Technology.

  • Received Date: 2021-02-20
  • Accepted Date: 2021-04-15
  • Rev Recd Date: 2021-03-31
  • Publish Date: 2021-05-20
    Abstract
  • The Arabidopsis thaliana RPD3-type histone deacetylases have been known to form conserved SIN3-type histone deacetylase complexes, but whether they form other types of complexes is unknown. Here, we perform affinity purification followed by mass spectrometry and demonstrate that the Arabidopsis RPD3-type histone deacetylases HDA6 and HDA19 interact with several previously uncharacterized proteins, thereby forming three types of plant-specific histone deacetylase complexes, which we named SANT, ESANT, and ARID. RNA-seq indicates that the newly identified components function together with HDA6 and HDA19 and coregulate the expression of a number of genes. HDA6 and HDA19 were previously thought to repress gene transcription by histone deacetylation. We find that the histone deacetylase complexes can repress gene expression via both histone deacetylation-dependent and -independent mechanisms. In the mutants of histone deacetylase complexes, the expression of a number of stress-induced genes is up-regulated, and several mutants of the histone deacetylase complexes show severe retardation in growth. Considering that growth retardation is thought to be a trade-off for an increase in stress tolerance, we infer that the histone deacetylase complexes identified in this study prevent over-expression of stress-induced genes and thereby ensure normal growth of plants under nonstress conditions.
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