Why is oocyte aneuploidy increased with maternal aging?

Jun-Yu Ma; Sen Li; Lei-Ning Chen; Heide Schatten; Xiang-Hong Ou; Qing-Yuan Sun

doi:10.1016/j.jgg.2020.04.003

Volume 47 Issue 11

Nov. 2020

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Article Navigation > Journal of Genetics and Genomics > 2020 > 47(11): 659-671

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Why is oocyte aneuploidy increased with maternal aging?

doi: 10.1016/j.jgg.2020.04.003

a
Fertility Preservation Lab, Reproductive Medicine Center, Guangdong Second Provincial General Hospital, Guangzhou, 510317, China
b
Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211, USA
c
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China

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Corresponding author: E-mail address: sunqy@gd2h.org.cn (Qing-Yuan Sun)
Publish Date: 2020-11-25

Abstract

Abstract

One of the main causes of pregnancy failure and fetus abortion is oocyte aneuploidy, which is increased with maternal aging. Numerous possible causes of oocyte aneuploidy in aged women have been proposed, including cross-over formation defect, cohesin loss, spindle deformation, spindle assembly checkpoint malfunction, microtubule-kinetochore attachment failure, kinetochore mis-orientation, mitochondria dysfunction-induced increases in reactive oxygen species, protein over-acetylation, and DNA damage. However, it still needs to be answered if these aneuploidization factors have inherent relations, and how to prevent chromosome aneuploidy in aged oocytes. Epidemiologically, oocyte aneuploidy has been found to be weakly associated with higher homocysteine concentrations, obesity, ionizing radiation and even seasonality. In this review, we summarize the research progress and present an integrated view of oocyte aneuploidization.
- Aging,
- Oocyte,
- Aneuploidy,
- Cohesin,
- SAC,
- Spindle,
- Mitochondria,
- Meiosis,
- DNA damage

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References(146)

References

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