Asthma-associated polymorphisms in 17q12-21 locus modulate methylation and gene expression of GSDMA in naïve CD4+ T cells

Anne-Marie Madore; Lucile Pain; Anne-Marie Boucher-Lafleur; Andréanne Morin; Jolyane Meloche; Marie-Michelle Simon; Bing Ge; Tony Kwan; Warren A. Cheung; Tomi Pastinen; Catherine Laprise

doi:10.1016/j.jgg.2020.03.002

Volume 47 Issue 3

Mar. 2020

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Asthma-associated polymorphisms in 17q12-21 locus modulate methylation and gene expression of GSDMA in naïve CD4+ T cells

doi: 10.1016/j.jgg.2020.03.002

1
Département des sciences fondamentales, Université du Québec à Chicoutimi, Saguenay, Quebec, G7H 2B1, Canada
2
Department of Human Genetics, McGill University, Montréal, Quebec, H3A 0C7, Canada
3
Department of Human Genetics, University of Chicago, IL, 60637, USA
4
Département des sciences fondamentales, Université du Québec à Chicoutimi, Saguenay, Quebec, G7H 2B1, Canada
5
McGill University and Genome Québec Innovation Centre, Montréal, Quebec, H3A 0G1, Canada
6
McGill University and Genome Québec Innovation Centre, Montréal, Quebec, H3A 0G1, Canada
7
Department of Human Genetics, McGill University, Montréal, Quebec, H3A 0C7, Canada
8
McGill University and Genome Québec Innovation Centre, Montréal, Quebec, H3A 0G1, Canada
9
Department of Human Genetics, McGill University, Montréal, Quebec, H3A 0C7, Canada
10
Center for Pediatric Genomic Medicine, Kansas City, MO, 64108, USA
11
Département des sciences fondamentales, Université du Québec à Chicoutimi, Saguenay, Quebec, G7H 2B1, Canada
12
Centre intersectoriel en santé durable, Université du Québec à Chicoutimi, Saguenay, Quebec, G7H 2B1, Canada

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Corresponding author: E-mail address: catherine.laprise@uqac.ca (Catherine Laprise)
Publish Date: 2020-03-25

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References(10)

References

[1]	P. J. Barnes Cellular and molecular mechanisms of asthma and COPD Clin Sci (Lond), 131(2017), pp. 1541-1558
[2]	W. A. Cheung, X. Shao, A. Morin, V. Siroux, T. Kwan, B. Ge, D. Aissi, L. Chen, L. Vasquez, F. Allum, F. Guenard, E. Bouzigon, M. M. Simon, E. Boulier, A. Redensek, S. Watt, A. Datta, L. Clarke, P. Flicek, D. Mead, D. S. Paul, S. Beck, G. Bourque, M. T. Lathrop, A. chernof, M. C. Vohl, F. Demenais, I. Pin, K. Downes, H. G. Stunnenberg, N. Soranzo, T. Pastinen and E. Grundberg Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome Genome Biol, 18(2017), pp. 50
[3]	J. Ding, K. Wang, W. Liu, Y. She, Q. Sun, J. Shi, H. Sun, D.C. Wang and F. Shao Pore-forming activity and structural autoinhibition of the gasdermin family Nature, 535(2016), pp. 111-116
[4]	M. A. R. Ferreira, R. Mathur, J. M. Vonk, A. Szwajda, B. Brumpton, R. Granell, B. K. Brew, V. Ullemar, Y. Lu, Y. Jiang, P. K. E. Magnusson, R. Karlsson, D. A. Hinds, L. Paternoster, G. H. Koppelman and C. Almqvist Genetic architectures of childhood- and adult-onset asthma are partly distinct. Am J Hum Genet, 104(2019), pp. 665-684
[5]	H. Heyn A symbiotic liaison between the genetic and epigenetic code Front Genet, 5(2014), pp. 113
[6]	A. M. Madore, K. Tremblay, T. J. Hudson and C. Laprise Replication of an association between 17q21 SNPs and asthma in a French-Canadian familial collection Hum Genet, 123(2008), pp. 93-95
[7]	M. Pividori, N. Schoettler, D. L. Nicolae, C. Ober and H. K. Im Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies Lancet Respir Med, 7(2019), pp. 509-522
[8]	L. E. Reinius, N. Acevedo, M. Joerink, G. Pershagen, S. E. Dahlen, D. Greco, C. Soderhall, A. Scheynius and J. Kere Differential DNA methylation in purified human blood cells: implications for cell lineage and studies on disease susceptibility PLoS One, 7(2012), pp. e41361
[9]	M. M. Stein, E. E. Thompson, N. Schoettler, B. A. Helling, K. M. Magnaye, C. Stanhope, C. Igartua, A. Morin, C. 3rd Washington, D. Nicolae, K. Bonnelykke and C. Ober A decade of research on the 17q12-21 asthma locus: Piecing together the puzzle J Allergy Clin Immunol, 142(2018), pp. 749-764 e743
[10]	Xavier , M.J., Roman, S.D., Aitken, R.J., Nixon , B., 2019. Transgenerational inheritance: how impacts to the epigenetic and genetic information of parents affect offspring health. Hum. Reprod. Update 25, 518–540.