Lessons from expanded potential of embryonic stem cells: Moving toward totipotency

Rongrong Le; Yixin Huang; Anqi Zhao; Shaorong Gao

doi:10.1016/j.jgg.2020.02.003

Volume 47 Issue 3

Mar. 2020

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Article Navigation > Journal of Genetics and Genomics > 2020 > 47(3): 123-130

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Lessons from expanded potential of embryonic stem cells: Moving toward totipotency

doi: 10.1016/j.jgg.2020.02.003

Clinical and Translational Research Center of Shanghai First Maternity & Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China

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Corresponding author: E-mail address: gaoshaorong@tongji.edu.cn (Shaorong Gao)
Publish Date: 2020-03-25

Abstract

Abstract

Embryonic stem cells possess fascinating capacity of self-renewal and developmental potential, leading to significant progress in understanding the molecular basis of pluripotency, disease modeling, and reprogramming technology. Recently, 2-cell–like embryonic stem cells (ESCs) and expanded potential stem cells or extended pluripotent stem cells (EPSCs) generated from early-cleavage embryos display some features of totipotent embryos. These cell lines provide valuable in vitro models to study underlying principles of totipotency, cell plasticity, and lineage segregation. In this review, we summarize the current progress in this filed and highlight the application potentials of these cells in the future.
- 2C-like ESC,
- EPSC,
- MERVL,
- Totipotency

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References(79)

References

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