Acquisition of functional neurons by direct conversion: Switching the developmental clock directly

Shuangquan Chen; Juan Zhang; Dongming Zhang; Jianwei Jiao

doi:10.1016/j.jgg.2019.10.003

Volume 46 Issue 10

Oct. 2019

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Article Navigation > Journal of Genetics and Genomics > 2019 > 46(10): 459-465

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Acquisition of functional neurons by direct conversion: Switching the developmental clock directly

doi: 10.1016/j.jgg.2019.10.003

Shuangquan Chen^{b, #},
Juan Zhang^{a, #},
Dongming Zhang^{a, #},
Jianwei Jiao^{a, c, d, e}

a
Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China
b
School of Pharmaceutical Sciences, Tsinghua University, Beijing, 100084, China
c
University of Chinese Academy of Sciences, Beijing, 100049, China
d
Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China
e
Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China

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Corresponding author: E-mail address: jwjiao@ioz.ac.cn (Jianwei Jiao)
Received Date: 2019-08-16
Accepted Date: 2019-10-08
Rev Recd Date: 2019-09-20

Available Online: 2019-10-28

Publish Date: 2019-10-20

Abstract

Abstract

Identifying approaches for treating neurodegeneration is a thorny task but is important for a growing number of patients. Researchers have focused on discovering the underlying molecular mechanisms of reprogramming and optimizing the technologies for acquiring neurons. Direct conversion is one of the most important processes for treating neurological disorders. Induced neurons derived from direct conversion, which bypass the pluripotency stage, are more effective, more quickly obtained, and are safer than those produced via induced pluripotent stem cells (iPSCs). Based on iPSC strategies, scientists have derived methods to obtain functional neurons by direct conversion, such as neuron-related transcriptional factors, small molecules, microRNAs, and epigenetic modifiers. In this review, we discuss the present strategies for direct conversion of somatic cells into functional neurons and the potentials of direct conversion for producing functional neurons and treating neurodegeneration.
- Direct conversion,
- Fibroblasts,
- Induced neurons,
- Neurodegeneration

These authors contributed equally to this work.

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References(90)

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