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Volume 45 Issue 10
Oct.  2018
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Article Contents

Instability of microsatellites linked to targeted genes in CRISPR/Cas9-edited and traditional gene knockout mouse strains

doi: 10.1016/j.jgg.2018.07.010
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  • Corresponding author: E-mail address: duduyan@ccmu.edu.cn (Xiaoyan Du)
  • Received Date: 2018-01-16
  • Accepted Date: 2018-07-04
  • Rev Recd Date: 2018-05-24
  • Available Online: 2018-10-10
  • Publish Date: 2018-10-20
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    Fu, Y., Foden, J.A., Khayter, C. et al. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells Nat. Biotechnol., 31 (2013),pp. 822-826
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    Gerlai, R. Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? Trends Neurosci., 19 (1996),pp. 177-181
    [3]
    Ho, B.X., Loh, S.J.H., Chan, W.K. et al. Int. J. Mol. Sci., 19 (2018)
    [4]
    Hsu, P.D., Scott, D.A., Weinstein, J.A. et al. DNA targeting specificity of RNA-guided Cas9 nucleases Nat. Biotechnol., 31 (2013),pp. 827-832
    [5]
    Huo, X., Du, Y., Lu, J. et al. Analysis of microsatellite instability in CRISPR/Cas9 editing mice Mutat. Res., 797–799 (2017),pp. 1-6
    [6]
    Moorehead, R.A., Sanchez, O.H., Baldwin, R.M. et al. Transgenic overexpression of IGF-II induces spontaneous lung tumors: a model for human lung adenocarcinoma Oncogene, 22 (2003),pp. 853-857
    [7]
    Schaefer, K.A., Wu, W.H., Colgan, D.F. et al. Nat. Methods, 14 (2017),pp. 547-548
    [8]
    Teng, X., Dayhoff-Brannigan, M., Cheng, W.C. et al. Genome-wide consequences of deleting any single gene Mol. Cell, 52 (2013),pp. 485-494
    [9]
    Zhang, F., Wen, Y., Guo, X. CRISPR/Cas9 for genome editing: progress, implications and challenges Hum. Mol. Genet., 23 (2014),pp. 40-46
    [10]
    Zuo, B., Du, X., Zhao, J. et al. Analysis of microsatellite polymorphism in inbred knockout mice PLoS One, 7 (2012),p. e34555
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