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Volume 45 Issue 4
Apr.  2018
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Article Navigation >  Journal of Genetics and Genomics  > 2018  >  45(4): 205-214

DNA methylation-mediated repression of miR-181a/135a/302c expression promotes the microsatellite-unstable colorectal cancer development and 5-FU resistance via targeting PLAG1

doi: 10.1016/j.jgg.2018.04.003
  • a 

    Department of Molecular Biology, Institute of Basic Medicine, School of Life Sciences, Chinese PLA General Hospital, Beijing 100086, China

  • b 

    Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing 100086, China

More Information
  • Corresponding author: E-mail address: meiqnn@hotmail.com (Qian Mei); E-mail address: hanwdrsw69@yahoo.com (Weidong Han)
  • Received Date: 2017-10-30
  • Accepted Date: 2018-04-08
  • Rev Recd Date: 2018-04-06
    • Available Online: 2018-04-13
  • Publish Date: 2018-04-20
    Abstract
  • Microsatellite instability (MSI) defines a subtype of colorectal cancer (CRC) with typical clinicopathologic characteristics. CRCs with MSI (MSI CRCs) frequently acquire accelerated carcinogenesis and 5-FU resistance, and the exact underlying mechanism remains incompletely understood. Our previous study has identified the microRNA (miRNA) expression profile in MSI CRCs. In this study, three miRNAs (miR-181a, miR-135a and miR-302c) were validated by qRT-PCR to be dramatically decreased in 67 CRC samples. Proliferation and apoptosis assays demonstrated that miR-181a/135a/302c function as tumor suppressors via repressing PLAG1/IGF2 signaling. Moreover, we presented compelling evidence that restoration of miR-181a/135a/302c expression promoted sensitivity of MSI CRC cells to 5-FU treatment. miR-181a/135a/302c exerted their effect on chemoresistance through attenuating PLAG1 expression. Notably, the hypermethylation status of MSI CRC accounts for the decrements of miR-181a/135a/302c. Our results contribute to a better understanding of the mechanism of chemoresistance in MSI CRCs, and provide a clue for digging the biomarkers and therapeutic targets for CRC patients.
    • These authors contributed equally to this study.
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    • References(46)
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