MicroRNA Signaling Pathway Network in Pancreatic Ductal Adenocarcinoma

Longhao Sun; Corrine Ying Xuan Chua; Weijun Tian; Zhixiang Zhang; Paul J. Chiao; Wei Zhang

doi:10.1016/j.jgg.2015.07.003

Volume 42 Issue 10

Oct. 2015

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Article Navigation > Journal of Genetics and Genomics > 2015 > 42(10): 563-577

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MicroRNA Signaling Pathway Network in Pancreatic Ductal Adenocarcinoma

doi: 10.1016/j.jgg.2015.07.003

a
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
b
Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston 77030, USA
c
The University of Texas Graduate School of Biomedical Sciences, Houston 77030, USA
d
Department of General Surgery, Tianjin Medical University General Hospital, Tianjin 300052, China

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Corresponding author: E-mail address: wzhang@mdanderson.org (Wei Zhang)
Received Date: 2015-05-23
Accepted Date: 2015-07-22
Rev Recd Date: 2015-07-16

Available Online: 2015-08-06

Publish Date: 2015-10-20

Abstract

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is considered to be the most lethal and aggressive malignancy with high mortality and poor prognosis. Their responses to current multimodal therapeutic regimens are limited. It is urgently needed to identify the molecular mechanism underlying pancreatic oncogenesis. Twelve core signaling cascades have been established critical in PDAC tumorigenesis by governing a wide variety of cellular processes. MicroRNAs (miRNAs) are aberrantly expressed in different types of tumors and play pivotal roles as post-transcriptional regulators of gene expression. Here, we will describe how miRNAs regulate different signaling pathways that contribute to pancreatic oncogenesis and progression.
- MicroRNA,
- Signaling pathway,
- Tumorigenesis,
- Pancreatic ductal adenocarcinoma

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