Pyrimidine Metabolism: Dynamic and Versatile Pathways in Pathogens and Cellular Development

Manuel F. Garavito; Heidy Y. Narváez-Ortiz; Barbara H. Zimmermann

doi:10.1016/j.jgg.2015.04.004

Volume 42 Issue 5

May 2015

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Pyrimidine Metabolism: Dynamic and Versatile Pathways in Pathogens and Cellular Development

doi: 10.1016/j.jgg.2015.04.004

Department of Biological Sciences, Los Andes University, Bogota, Colombia

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Corresponding author: E-mail address: bhzimmermann@bhzonline.net (Barbara H. Zimmermann)
Received Date: 2014-11-21
Accepted Date: 2015-04-14
Rev Recd Date: 2015-04-13

Available Online: 2015-05-08

Publish Date: 2015-05-20

Abstract

Abstract

The importance of pyrimidines lies in the fact that they are structural components of a broad spectrum of key molecules that participate in diverse cellular functions, such as synthesis of DNA, RNA, lipids, and carbohydrates. Pyrimidine metabolism encompasses all enzymes involved in the synthesis, degradation, salvage, interconversion and transport of these molecules. In this review, we summarize recent publications that document how pyrimidine metabolism changes under a variety of conditions, including, when possible, those studies based on techniques of genomics, transcriptomics, proteomics, and metabolomics. First, we briefly look at the dynamics of pyrimidine metabolism during nonpathogenic cellular events. We then focus on changes that pathogen infections cause in the pyrimidine metabolism of their host. Next, we discuss the effects of antimetabolites and inhibitors, and finally we consider the consequences of genetic manipulations, such as knock-downs, knock-outs, and knock-ins, of pyrimidine enzymes on pyrimidine metabolism in the cell.
- Pyrimidine metabolism,
- Pathogens,
- CAD,
- Dihydroorotase,
- Dihydroorotate dehydrogenase,
- UMP synthase

These authors contributed equally to this work.

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References(58)

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