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Volume 41 Issue 5
May  2014
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Article Navigation >  Journal of Genetics and Genomics  > 2014  >  41(5): 251-259

Recent Advances in Understanding Proteins Involved in Lipid Droplet Formation, Growth and Fusion

doi: 10.1016/j.jgg.2014.03.003
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    Signature Research Program in Cardiovascular & Metabolic Disorders, Duke-NUS Graduate Medical School Singapore, Singapore 169857, Singapore

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  • Corresponding author: E-mail address: david.silver@duke-nus.edu.sg (David L. Silver)
  • Received Date: 2013-10-25
  • Accepted Date: 2014-03-05
  • Rev Recd Date: 2014-03-03
    • Available Online: 2014-03-19
  • Publish Date: 2014-05-20
    Abstract
  • Lipid droplets (LDs) were once viewed as simple, inert lipid micelles. However, they are now known to be organelles with a rich proteome involved in a myriad of cellular processes. LDs are heterogeneous in nature with different sizes and compositions of phospholipids, neutral lipids and proteins. This review takes a focused look at the roles of proteins involved in the regulation of LD formation, expansion, and morphology. The related proteins are summarized such as the fat-specific protein (Fsp27), fat storage-inducing transmembrane (FIT) proteins, seipin and ADP-ribosylation factor 1-coat protein complex I (Arf-COPI). Finally, we present important challenges in LD biology for a deeper understanding of this dynamic organelle to be achieved.
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