Roles of MicroRNAs in the Caenorhabditis elegans Nervous System

Lingfeng Meng; Liang Chen; Zhaoyong Li; Zheng-Xing Wu; Ge Shan

doi:10.1016/j.jgg.2013.07.002

Volume 40 Issue 9

Sep. 2013

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Article Navigation > Journal of Genetics and Genomics > 2013 > 40(9): 445-452

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Roles of MicroRNAs in the Caenorhabditis elegans Nervous System

doi: 10.1016/j.jgg.2013.07.002

a
School of Life Science and Technology, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, China
b
School of Life Sciences & CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China, 443 Huangshan Road, Hefei 230027, China

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Corresponding author: E-mail address: ibbwuzx@mail.hust.edu.cn (Zheng-Xing Wu); E-mail address: shange1@hotmail.com (Ge Shan)
Received Date: 2013-04-12
Accepted Date: 2013-07-08
Rev Recd Date: 2013-07-05

Available Online: 2013-08-07

Publish Date: 2013-09-20

Abstract

Abstract

The first microRNA was discovered in Caenorhabditis elegans in 1993, and since then, thousands of microRNAs have been identified from almost all eukaryotic organisms examined. MicroRNAs function in many biological events such as cell fate determination, metabolism, apoptosis, and carcinogenesis. So far, more than 250 microRNAs have been identified in C. elegans; however, functions for most of these microRNAs are still unknown. A small number of C. elegans microRNAs are associated with known physiological roles such as developmental timing, cell differentiation, stress response, and longevity. In this review, we summarize known roles of microRNAs in neuronal differentiation and function ofC. elegans, and discuss interesting perspectives for future studies.
- Nervous system,
- MicroRNA,
- Function,
- Differentiation

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References(62)

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