Transgenic Nonhuman Primate Models for Human Diseases: Approaches and Contributing Factors

Yongchang Chen; Yuyu Niu; Weizhi Ji

doi:10.1016/j.jgg.2012.04.007

Volume 39 Issue 6

Jun. 2012

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Article Navigation > Journal of Genetics and Genomics > 2012 > 39(6): 247-251

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Transgenic Nonhuman Primate Models for Human Diseases: Approaches and Contributing Factors

doi: 10.1016/j.jgg.2012.04.007

Yongchang Chen^{a, b},
Yuyu Niu^{a, b},
Weizhi Ji^{a, c}

a
Yunnan Key Laboratory of Primate Biomedical Research, Kunming 650500, China
b
Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
c
Kunming Biomed International and National Engineering Research Center of Biomedicine and Animal Science, Kunming 650500, China

More Information

Corresponding author: E-mail address: niuyy@mail.kiz.ac.cn (Yuyu Niu); E-mail address: wji@kbimed.com (Weizhi Ji)
Received Date: 2012-03-22
Accepted Date: 2012-04-30
Rev Recd Date: 2012-04-29

Available Online: 2012-05-16

Publish Date: 2012-06-20

Abstract

Abstract

Nonhuman primates (NHPs) provide powerful experimental models to study human development, cognitive functions and disturbances as well as complex behavior, because of their genetic and physiological similarities to humans. Therefore, NHPs are appropriate models for the study of human diseases, such as neurodegenerative diseases including Parkinson's, Alzheimer's and Huntington's diseases, which occur as a result of genetic mutations. However, such diseases afflicting humans do not occur naturally in NHPs. So transgenic NHPs need to be established to understand the etiology of disease pathology and pathogenesis. Compared to rodent genetic models, the generation of transgenic NHPs for human diseases is inefficient, and only a transgenic monkey model for Huntington's disease has been reported. This review focuses on potential approaches and contributing factors for generating transgenic NHPs to study human diseases.
- Nonhuman primates,
- Disease model,
- Transgenesis

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References(44)

References

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