Deciphering tumor-suppressor signaling in flies: Genetic link between Scribble/Dlg/Lgl and the Hippo pathways

Masato Enomoto; Tatsushi Igaki

doi:10.1016/j.jgg.2011.09.005

Volume 38 Issue 10

Oct. 2011

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Deciphering tumor-suppressor signaling in flies: Genetic link between Scribble/Dlg/Lgl and the Hippo pathways

doi: 10.1016/j.jgg.2011.09.005

Masato Enomoto^a,
Tatsushi Igaki^{a, b}

a
Department of Cell Biology, G-COE, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
b
Japan Science and Technology Agency, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan

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Corresponding author: E-mail address: igaki@med.kobe-u.ac.jp (Tatsushi Igaki)
Received Date: 2011-07-20
Accepted Date: 2011-09-02
Rev Recd Date: 2011-09-02

Available Online: 2011-09-17

Publish Date: 2011-10-20

Abstract

Abstract

Loss of apico-basal polarity is one of the crucial factors that drives epithelial tumor progression. scribble/discs large/lethal giant larvae (scrib/dlg/lgl), a group of apico-basal polarity genes, were initially identified as members of “neoplastic” tumor-suppressors in flies. The components of the Hippo signaling pathway, which is crucial for organ size control and cancer development, were also identified through Drosophila genetic screens as members of “hyperplastic” tumor-suppressors. Accumulating evidence in recent studies implies that these two tumor-suppressor signaling pathways are not mutually exclusive but rather cooperatively act to give rise to highly malignant tumors. The interaction of these tumor-suppressor pathways could include deregulations of actin cytoskeleton, cell–cell contact, and apical-domain size of the epithelial cell.
- Cell polarity,
- Hippo pathway,
- Tumor-suppressor,
- Tumor progression

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References(112)

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