Analysis of MIF, FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan population

Khalid Sadki; Hoda Lamsyah; Blanca Rueda; ELmahfoud Akil; Abderrahim Sadak; Javier Martin; Rajae El Aouad

doi:10.1016/S1673-8527(09)60044-8

Volume 37 Issue 4

Apr. 2010

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Article Navigation > Journal of Genetics and Genomics > 2010 > 37(4): 257-264

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Analysis of MIF, FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan population

doi: 10.1016/S1673-8527(09)60044-8

a
Human Genomic Unit, Laboratory of Immunology, National Institute of Hygiene, Rabat 10000, Morocco
b
Department of Immunology, Instituto de Parasitología y Biomedicina López-Neyra, CSIC, 18100 Armilla, Granada, Spain
c
National Reference Laboratory of Tuberculosis, National Institute of Hygiene, Rabat 10000, Morocco
d
Department of Biology, Faculty of Sciences, University Mohammed V –Rabat Agdal 10000, Morocco
e
Immunology and Virology Department, National Institute of Hygiene, Rabat 10000, Morocco

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Corresponding author: E-mail address: ksadki1@yahoo.fr (Khalid Sadki)
Received Date: 2009-10-25
Accepted Date: 2010-02-24
Rev Recd Date: 2010-02-09

Available Online: 2010-05-01

Publish Date: 2010-04-20

Abstract

Abstract

In order to investigate the influence of functional polymorphisms of macrophage migration inhibitory factor (MIF), Fcg receptors CD16A (FCGR3A) and CD32A (FCGR2A) genes on susceptibility to pulmonary tuberculosis (PTB) in the Moroccan population, we analyzed 123 patients with PTB and 154 healthy controls. The genotyping for MIF–173 (G/C) (rs755622), FCGR2A-131H/R (rs1801274) and FCGR3A-158V/F (rs396991) was carried out using TaqMan SNP Genotyping Assay method. We found a statistically significant increase of the MIF −173CC homozygote genotype and MIF −173*C allele frequencies in PTB patients compared with healthy controls (17.07% versus 5.84%, P = 0.003; and 35.37% versus 26.30%, P = 0.02; respectively). In contrast, no association was observed between FCGR2A-131H/R and FCGR3A-158V/F polymorphisms and tuberculosis disease. Our finding suggests that MIF −173*C variant may play an important role in the development of active tuberculosis.
- FCGR,
- MIF,
- polymorphism,
- susceptibility,
- pulmonary tuberculosis,
- Moroccan

These authors share senior authorship in this study.

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References(48)

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