Polymorphic Alu insertions and their associations with MHC class I alleles and haplotypes in Han and Jinuo populations in Yunnan Province, southwest of China

Yufeng Yao; Li Shi; Lei Shi; Keqin Lin; Yufen Tao; Liang Yu; Hao Sun; Xiaoqin Huang; Yanhan Li; Jiayou Chu

doi:10.1016/S1673-8527(09)60006-0

Volume 36 Issue 1

Jan. 2009

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Article Navigation > Journal of Genetics and Genomics > 2009 > 36(1): 51-58

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Polymorphic Alu insertions and their associations with MHC class I alleles and haplotypes in Han and Jinuo populations in Yunnan Province, southwest of China

doi: 10.1016/S1673-8527(09)60006-0

Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China

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Corresponding author: E-mail address: chujy@imbcams.com.cn (Jiayou Chu)
Received Date: 2008-07-14
Accepted Date: 2008-10-23
Rev Recd Date: 2008-10-15

Available Online: 2009-01-20

Publish Date: 2009-01-20

Abstract

Abstract

The associations of polymorphic Alu insertions (POALINs) with major histocompatibility complex (MHC) class I genes enable us to better identify origins and evolution of MHC class I region haplotypes in different populations. For further studying origins and evolution of MHC class I region haplotypes in Han and Jinuo populations in Yunnan Province, we investigated frequencies of five POALINs, their associations with HLA-A and -B, the three-loci POALINs haplotype frequencies and HLA/POALIN four-loci haplotype frequencies within the alpha block of MHC class I region. We found that a strong positive association between AluHG and HLA-A*02 is in Jinuo, but not in Yunnan Han. These results suggest that MHC class I region haplotypes of the two studied populations might derive from different progenitor haplotypes and MHC I-POALINs are informative genetic markers for investigating origins and evolution of MHC class I region haplotypes in different populations.
- MHC I,
- haplotype,
- POALINs

These authors contributed equally to this work.

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References(20)

References

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