Mitochondrial variants may influence the phenotypic manifestation of Leber's hereditary optic neuropathy-associated ND4 G11778A mutation

Wanshi Cai; Qun Fu; Xiangtian Zhou; Jia Qu; Yi Tong; Min-Xin Guan

doi:10.1016/S1673-8527(08)60086-7

Volume 35 Issue 11

Nov. 2008

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Article Navigation > Journal of Genetics and Genomics > 2008 > 35(11): 649-655

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Mitochondrial variants may influence the phenotypic manifestation of Leber's hereditary optic neuropathy-associated ND4 G11778A mutation

doi: 10.1016/S1673-8527(08)60086-7

Wanshi Cai^{a, b, #},
Qun Fu^{c, #},
Xiangtian Zhou^b,
Jia Qu^b,
Yi Tong^{a, d},
Min-Xin Guan^{a, b, e}

a
Zhejiang Provincial Key Laboratory of Medical Genetics, School of Life Sciences, Wenzhou Medical College, Wenzhou 325035, China
b
School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou 325003, China
c
The Third Affiliated Hospital, Xinxiang Medical College, Xinxiang 453003, China
d
The First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China
e
Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA

More Information

Corresponding author: E-mail address: gminxin88@gmail.com (Min-Xin Guan)
Received Date: 2008-04-07
Accepted Date: 2008-10-07
Rev Recd Date: 2008-10-02

Available Online: 2008-11-18

Publish Date: 2008-11-20

Abstract

Abstract

We report here the characterization of a five-generation Han Chinese family with Leber's hereditary optic neuropathy (LHON). Strikingly, this Chinese family displayed high penetrance and expressivity of visual loss. The average age-of-onset of vision loss was 18 years in this family. Nineteen (11 males/8 females) of 29 matrilineal relatives in this family developed visual loss with a wide range of severity, ranging from blindness to normal vision. Sequence analysis of mitochondrial genome in this pedigree revealed the presence of the ND4 G11778A mutation and 44 other variants belonging to Asian haplogroup M7b. The G11778A mutation is present at homoplasmy in matrilineal relatives of this Chinese family. Of other variants, the CO1 G6480A, ND5 T12811C and Cytb A15395G located at highly conserved residues of corresponding polypeptides. In fact, these variants were implicated to be involved in other clinical abnormalities. Here, these variants may act in synergy with the primary LHON-associated G11778A mutation. Thus, the mitochondrial dysfunction caused by the primary ND4 G11778A mutation may be worsened by these mitochondrial variants. The results imply that the G6480A, T12811C and A15395G variants might have a potential modifier role in increasing the penetrance and expressivity of the primary LHON-associated G11778A mutation in this Chinese family.
- Leber's hereditary optic neuropathy,
- mitochondrial DNA,
- mutation,
- haplotype,
- vision loss,
- modifier,
- Chinese

These authors contributed equally to this work.

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References(26)

References

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