Genome-wide mapping of conserved microRNAs and their host transcripts in Tribolium castaneum

Qibin Luo; Qing Zhou; Xiaomin Yu; Hongbin Lin; Songnian Hu; Jun Yu

doi:10.1016/S1673-8527(08)60051-X

Volume 35 Issue 6

Jun. 2008

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Genome-wide mapping of conserved microRNAs and their host transcripts in Tribolium castaneum

doi: 10.1016/S1673-8527(08)60051-X

Qibin Luo^{a, b, #},
Qing Zhou^{b, c, #},
Xiaomin Yu^{b, c},
Hongbin Lin^{b, c},
Songnian Hu^{a, b},
Jun Yu^{a, b}

a
James D. Watson Institute of Genome Sciences, Zhejiang University, Hangzhou 310008, China
b
Key Laboratory of Genome Information and Sciences, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China
c
Graduated School of the Chinese Academy of Sciences, Beijing 100049, China

More Information

Corresponding author: E-mail address: junyu@big.ac.cn (Jun Yu)
Received Date: 2007-10-29
Accepted Date: 2008-03-19
Rev Recd Date: 2008-03-18

Available Online: 2008-06-18

Publish Date: 2008-06-20

Abstract

Abstract

MicroRNAs (miRNAs) are endogenous 22-nt RNAs, which play important regulatory roles by post-transcriptional gene silencing. A computational strategy has been developed for the identification of conserved miRNAs based on features of known metazoan miRNAs in red flour beetle (Tribolium castaneum), which is regarded as one of the major laboratory models of arthropods. Among 118 putative miRNAs, 47% and 53% of the predicted miRNAs from the red flour beetle are harbored by known protein-coding genes (intronic) and genes located outside (intergenic miRNA), respectively. There are 31 intronic miRNAs in the same transcriptional orientation as the host genes, which may share RNA polymerase II and spliceosomal machinery with their host genes for their biogenesis. A hypothetical feedback model has been proposed based on the analysis of the relationship between intronic miRNAs and their host genes in the development of red flour beetle.
- miRNA,
- host transcript,
- intronic miRNA,
- Tribolium castaneum

These authors contributed equally to this work.

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References(48)

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