Adiponectin and its association with insulin resistance and type 2 diabetes

Tianxin Sheng; Kangjuan Yang

doi:10.1016/S1673-8527(08)60047-8

Volume 35 Issue 6

Jun. 2008

Turn off MathJax

Article Contents

Article Navigation > Journal of Genetics and Genomics > 2008 > 35(6): 321-326

PDF( 182 KB)

Adiponectin and its association with insulin resistance and type 2 diabetes

doi: 10.1016/S1673-8527(08)60047-8

School of Basic Medicine, Yanbian University, Yanji 133000, China

More Information

Corresponding author: E-mail address: yangkj@ybu.edu.cn (Kangjuan Yang)
Received Date: 2007-12-25
Accepted Date: 2008-03-18
Rev Recd Date: 2008-03-14

Available Online: 2008-06-18

Publish Date: 2008-06-20

Abstract

Abstract

Adiponectin is an adipokine, which is expressed in adipose tissue and is thought to play an important role in glucose metabolism. Hypoadiponectinemia can cause reduction of fatty acid oxidation, decreased glucose uptake in skeletal muscle cells, and increased gluconeogenesis in hepatic cells. The level of plasma glucose can be increased. On the other hand, the decrease of fatty acid oxidation increases the level of free fatty acid (FFA), which increases the insulin resistance, and then decreases the glucose uptake, which ultimately causes increased plasma glucose and type 2 diabetes (T2D). This review describes the process from hypoadiponectinemia to T2D and the genesis of hypoadiponectinemia at a molecular level.
- adiponectin,
- insulin resistance,
- type 2 diabetes,
- hypoadiponectinemia

FullText(HTML)

References(55)

References

[1]	Beltowski, J. Adiponectin and resistin-new hormones of white adipose tissue Med. Sci. Monit., 9 (2003),pp. RA55-RA61
[2]	Chuang, L.M., Chiu, Y.F., Sheu, W.H. et al. Biethnic comparisons of autosomal genomic scan for loci linked to plasma adiponectin in populations of Chinese and Japanese origin J. Clin. Endocrinol. Metab., 89 (2004),pp. 5772-5778
[3]	Daimon, M., Oizumi, T., Saitoh, T. et al. Decreased serum levels of adiponectin are a risk factor for the progression to type 2 diabetes in the Japanese population: The Funagata study Diabetes Care, 26 (2003),pp. 2015-2020
[4]	Dresner, A., Laurent, D., Marcucci, M. et al. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity J. Clin. Invest, 103 (1999),pp. 253-259
[5]	Duncan, B.B., Schmidt, M.I., Pankow, J.S. et al. Adiponectin and the development of type 2 diabetes: The atherosclerosis risk in communities study Diabetes, 53 (2004),pp. 2473-2478
[6]	Evans, R.M., Barish, G.D., Wang, Y.X. PPARs and the complex journey to obesity Nat. Med., 10 (2004),pp. 355-361
[7]	Frieman, J.M. Obesity in the new millennium Nature, 404 (2000),pp. 632-634
[8]	Griffin, M.E., Marcucci, M.J., Cline, G.W. et al. Free fatty acid-induced insulin resistance is associated with activity of protein kinase C theta and alterations in the insulin signaling cascade Diabetes, 48 (1999),pp. 1270-1274
[9]	Gu, H.F., Abulaiti, A., Östenson, C.G. et al. Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish Caucasians Diabetes, 53 (2004),pp. S31-S35
[10]	Guo, X., Saad, M.F., Langefeld, C.D. et al. Genome-wide linkage of plasma adiponectin reveals a major locus on chromosome 3q distinct from the adiponectin structural gene: The IRAS family study Diabetes, 55 (2006),pp. 1723-1730
[11]	Hara, K., Boutin, P., Mori, Y. et al. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population Diabetes, 51 (2002),pp. 536-540
[12]	Heid, I.M., Wagner, S.A., Gohlke, H. et al. Diabetes, 55 (2006),pp. 375-384
[13]	Hirose, H., Kawai, T., Yamamoto, Y. et al. Effects of pioglitazone on metabolic parameters, body fat distribution, and serum adiponectin levels in Japanese male patients with type 2 diabetes Metabolism, 51 (2002),pp. 314-317
[14]	Hotamisligil, G.S. The role of TNFα and TNF receptors in obesity and insulin resistance J. Intern. Med., 245 (1999),pp. 621-625
[15]	Hu, E., Liang, P., Spiegelman, B.M. J. Biol. Chem., 271 (1996),pp. 10697-10703
[16]	Hug, C., Wang, J., Ahmad, N.S. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin Proc. Natl. Acad. Sci. USA, 101 (2004),pp. 10308-10313
[17]	Iwaki, M., Matsuda, M., Maeda, N. et al. Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors Diabetes, 52 (2003),pp. 1655-1663
[18]	Kahn, S.E., Montgomery, B., Howell, W. et al. Importance of early phase insulin secrection to intravenous glucose tolerance in subjects with type 2 diabetes mellitus J. Clin. Endocrinol. Metab., 86 (2001),pp. 5824-5829
[19]	Kondo, H., Shimomura, I., Matsukawa, Y. et al. Association of adiponectin mutation with type 2 diabetes: A candidate gene for the insulin resistance syndrome Diabetes, 51 (2002),pp. 2325-2328
[20]	Krakoff, J., Funahashi, T., Stehouwer, C.D.A. et al. Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima Indian Diabetes Care, 26 (2003),pp. 1745-1751
[21]	Lindsay, R.S., Funahashi, T., Hanson, R.L. et al. Adiponectin and development of type 2 diabetes in the Pima Indian population Lancet, 360 (2002),pp. 57-58
[22]	Lindsay, R.S., Funahashi, T., Krakoff, J. et al. Genome-wide linkage analysis of serum adiponectin in the Pima Indian population Diabetes, 52 (2003),pp. 2419-2425
[23]	Mackevics, V., Heid, I.M., Wagner, S.A. et al. The adiponectin gene is associated with adiponectin levels but not with characteristics of the insulin resistance syndrome in healthy Caucasians Eur. J. Hum. Genet., 14 (2006),pp. 349-356
[24]	Maeda, K., Okubo, K., Shimomura, I. et al. cDNA cloning and expression of a novel adipose-specific collagen-like factor, apM1 (adipose most abundant gene transcript 1) Biochem. Biophys. Res. Commun., 221 (1996),pp. 286-289
[25]	Mao, X., Kikani, C.K., Riojas, R.A. et al. APPL1 binds to adiponectin receptors and mediates adiponectin signaling and function Nat. Cell Biol., 8 (2006),pp. 516-523
[26]	Menzaghi, C., Ercolino, T., Paola, R.D. et al. A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome Diabetes, 51 (2002),pp. 2306-2312
[27]	Menzaghi, C., Ercolino, T., Salvemini, L. et al. Physiol. Genomics, 19 (2004),pp. 170-174
[28]	Menzaghi, C., Trischitta, V., Doria, A. Genetic influences of adiponectin on insulin resistance, type 2 diabetes and cardiovascular disease Diabetes, 56 (2007),pp. 1198-1209
[29]	Mori, Y., Otabe, S., Dina, C. et al. Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate loci on 7p and 11p Diabetes, 51 (2002),pp. 1247-1255
[30]	Nakano, Y., Tobe, T., Choi-Miura, N.H. et al. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma J. Biochem., 120 (1996),pp. 803-812
[31]	Pajvani, U.B., Du, X., Combs, T.P. et al. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications for metabolic regulation and bioactivity J. Biol. Chem., 278 (2003),pp. 9073-9085
[32]	Pajvani, U.B., Hawkins, M., Combs, T.P. et al. Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity J. Biol. Chem., 279 (2004),pp. 12152-12162
[33]	Petrone, A., Zavarella, S., Caiazzo, A. et al. The promoter region of the adiponectin gene is a determinant in modulating insulin sensitivity in childhood obesity Obesity, 14 (2006),pp. 1498-1504
[34]	Pollin, T.I., Tanner, K., O'Connell, J.R. et al. Diabetes, 54 (2005),pp. 268-274
[35]	Richards, A.A., Stephens, T., Charlton, H.K. et al. Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: Evidence for regulation of multimerization by alterations in posttranslational modifications Mol. Endocrinol., 20 (2006),pp. 1673-1687
[36]	Scherer, P.E., William, S., Fogliano, M. et al. A novel serum protein similar to C1q, produced exclusively in adipocytes J. Biol. Chem., 270 (1995),pp. 26746-26749
[37]	Shapiro, L., Scherer, P.E. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor Curr. Biol., 8 (1998),pp. 335-338
[38]	Shimonura, I., Funahashi, T., Takahashi, M. et al. Enhanced expression of PAI-1 in visceral fat: Possible contributor to vascular disease in obesity Nat. Med., 2 (1996),pp. 800-803
[39]	Shulman, B.M., Flier, J.S. Adipogenesis and obesity: Rounding out the big picture Cell, 87 (1996),pp. 377-389
[40]	Snehalatha, C., Mukesh, B., Simon, M. et al. Plasma adiponectin is an independent predictor of type 2 diabetes in Asian Indians Diabetes Care, 26 (2003),pp. 3226-3229
[41]	Soliman, P.T., Wu, D., Tortolero-Luna, G. et al. Association between adiponectin, insulin resistance, and endometrial cancer Cancer, 106 (2006),pp. 2376-2381
[42]	Spranger, J., Kroke, A., Möhlig, M. et al. Adiponectin and protection against type 2 diabetes mellitus Lancet, 361 (2003),pp. 226-228
[43]	Steppan, C.M., Bailey, S.T., Bhat, S. et al. The hormone resistin links obesity to diabetes Nature, 409 (2001),pp. 307-312
[44]	Stumvoll, M., Tschritter, O., Fritsche, A. et al. Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: Interaction with family history of type 2 diabetes Diabetes, 51 (2002),pp. 37-41
[45]	Sutton, B.S., Weinert, S., Langefeld, C.D. et al. Genetic analysis of adiponectin and obesity in Hispanic families: The IRAS family study Hum. Genet., 117 (2005),pp. 107-118
[46]	Tso, A.W., Sham, P.C., Wat, N.M. et al. Polymorphisms of the gene encoding adiponectin and glycaemic outcome of Chinese subjects with impaired glucose tolerance: A 5-year follow-up study Diabetologia, 49 (2006),pp. 1806-1815
[47]	Vasseur, F., Helbecque, N., Dina, C. et al. Hum. Mol. Genet., 11 (2002),pp. 2607-2614
[48]	Vozarova de Courten, B., Hanson, R.L., Funahashi, T. et al. Diabetes, 54 (2005),pp. 284-289
[49]	Waki, H., Yamauchi, T., Kamon, J. et al. Impaired multimerization of human adiponectin mutants associated with diabetes J. Biol. Chem., 278 (2003),pp. 40352-40363
[50]	White, R.T., Damm, D., Hancock, N. et al. Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue J. Biol. Chem., 267 (1992),pp. 9210-9213
[51]	Wong, G.W., Wang, J., Hug, C. et al. A family of Acrp30/adiponectin structural and functional paralogs Proc. Natl. Acad. Sci. USA, 101 (2004),pp. 10302-10307
[52]	Yamamoto, Y., Hirose, H., Sairo, I. et al. Adiponectin, an adipocyte-derived protein, predicts future insulin-resistance: Two-year follow-up study in Japanese population J. Clin. Endocrinol. Metab., 89 (2004),pp. 87-90
[53]	Yamauchi, T., Kamon, J., Ito, Y. et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects Nature, 423 (2003),pp. 762-769
[54]	Yatagai, T. Hypoadiponectinemia is associated with visceral fat accumulation and insulin resistance in Japanese men with type 2 diabetes mellitus Metabolism, 52 (2003),pp. 1274-1278
[55]	Yu, J.G., Javorschi, S., Hevener, A.L. et al. The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects Diabetes, 51 (2002),pp. 2968-2974