Prepulse inhibition (PPI) of tactile startle response in recombinant congenic strains of mice: QTL mapping and comparison with acoustic PPI

Adam Torkamanzehi; Patricia Boksa; Ridha Joober

doi:10.1016/S1673-8527(08)60020-X

Volume 35 Issue 3

Mar. 2008

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Article Navigation > Journal of Genetics and Genomics > 2008 > 35(3): 139-151

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Prepulse inhibition (PPI) of tactile startle response in recombinant congenic strains of mice: QTL mapping and comparison with acoustic PPI

doi: 10.1016/S1673-8527(08)60020-X

a
University of Sistan and Baluchestan, Zahedan P.O. Box 98155-987, Iran
b
Douglas Hospital Research Centre, Montreal H4H 1R3, Canada
c
Department of Psychiatry, McGill University, Montreal H3A 1A1, Canada
d
Department of Human Genetics, McGill University, Montreal H3A 1B1, Canada

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Corresponding author: E-mail address: ridha.joober@douglas.mcgill.ca (Ridha Joober)
Received Date: 2007-05-01
Accepted Date: 2007-10-17
Rev Recd Date: 2007-09-25

Available Online: 2008-03-18

Publish Date: 2008-03-20

Abstract

Abstract

Prepulse inhibition (PPI) of the startle response is a psychophysiological measure of sensorimotor gating believed to be cross-modal between different sensory systems. We analyzed the tactile startle response (TSR) and PPI of TSR (tPPI), using light as a prepulse stimulus, in the mouse strains A/J and C57BL/6J and 36 recombinant congenic strains derived from them. Parental strains were significantly different for TSR, but were comparable for tPPI. Among the congenic strains, variation for TSR was significant in both genetic backgrounds, but that of tPPI was significant only for the C57BL/6J background. Provisional mapping for loci modulating TSR and tPPI was carried out. Using mapping data from our previous study on acoustic startle responses (ASR) and PPI of ASR (aPPI), no common markers for aPPI and tPPI were identified. However, some markers were significantly associated with both ASR and TSR, at least in one genetic background. These results indicate cross-modal genetic regulation for the startle response but not for PPI, in these mouse strains.
- tactile startle response,
- prepulse inhibition (PPI),
- acoustic startle response,
- recombinant congenic strains of mice,
- QTL mapping,
- microsatellite markers

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References(37)

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