New players in the regulation of ecdysone biosynthesis

Xun Huang; James T. Warren; Lawrence I. Gilbert

doi:10.1016/S1673-8527(08)60001-6

Volume 35 Issue 1

Jan. 2008

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Article Navigation > Journal of Genetics and Genomics > 2008 > 35(1): 1-10

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New players in the regulation of ecdysone biosynthesis

doi: 10.1016/S1673-8527(08)60001-6

a
Laboratory of Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China
b
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA

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Corresponding author: E-mail address: xhuang@genetics.ac.cn (Xun Huang); E-mail address: lgilbert@bio.unc.edu (Lawrence I. Gilbert)
Received Date: 2007-11-20
Accepted Date: 2007-11-24
Rev Recd Date: 2007-11-24

Available Online: 2008-01-25

Publish Date: 2008-01-20

Abstract

Abstract

Insect ecdysone steroid hormone regulates major developmental transitions, such as molting and metamorphosis. The production of ecdysone correlates well with the timing of these transitions. Finding out how the ecdysone biosynthesis is regulated is crucial to fully understand these sophisticated developmental switches. Here we summarized recent findings in the regulation of ecdysone biosynthesis from the aspects of cell signaling, key biosynthetic enzymes and substrate cholesterol trafficking.
- ecdysone,
- cholesterol,
- PTTH,
- P450

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References(51)

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